SCC604

3dGRO^® Human Lung Organoids (XDO.137)

Adenocarcinoma, Lung (Xenograph- Acinar/Papillary), Age: 69, Female, Mutation: EGFR E746_A750del

• Synonym(s): Lung PDO;Lung Tumor Organoid;Airway Organoid;Pulmonary Organoid, lung organoids
• UNSPSC Code: 41106509
• NACRES: NA.81

Properties

• Quality Level: 100
• biological source: human lung (Xenograph- Acinar/Papillary)
• packaging: vial of ≥ 1500 organoids/vial mg
• manufacturer/tradename: Millipore
• gender: female
• growth mode: N/A
• karyotype: 3D Organoid, normal
• technique(s): cell culture: suitable
• application(s): 3D cell culture
• control: lung (Xenograph- Acinar/Papillary)
• shipped in: liquid nitrogen
• storage temp.: −196°C

Description

Application

• Each vial contains > 1500 organoids.
• Mycoplasma: Negative
• Genotyped by STR analysis: Pass
• Human species verified
• Organoids are negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cell viability test: Pass

Patient-derived lung organoids (lung PDOs) are adult tissue derived in vitro cultured "mini-lungs" that accurately replicate the histological and functional aspects of in vivo lung tissue. Lung organoids have been shown to contain all 6 major lung epithelial cell types including AEC2s, AEC1s, basal cells, club cells, goblet cells and ciliated cells. These 3D organoid models have become attractive alternatives to traditional PDX and animal lung models to study pulmonary diseases including COPD, cystic fibrosis, SARS-CoV-2, viral infections, asthma, and lung cancer. The 3dGRO^® Human Lung Organoids are high quality cryopreserved cell lines derived from patient-derived xenografts, primary tumors or metastatic patient tissues from various regions of the human lung (acinar, papillary, solid, squamous, mucinous). These lung organoids are highly characterized and express lung airway markers including EPCAM, cytokeratin (CK5, CK7), acetyl-a-tubulin, surfactant proteins (SFTPB/SFTPC), TTF1, P63 and Muc5AC.
Cell Line Characteristics

• Sex: Female
• Age: 69
• Organ: Lung (PDX- Acinar/Papillary)
• Disease: Adenocarcinoma (Driver Mutations: EGFR E746_A750del)

Features and Benefits

Cryopreserved Female Adenocarcinoma Lung Organoids (Acinar/Papillary)

Preparation Note

3dGRO^® human lung organoids should be stored in liquid nitrogen.

Legal Information

3dGRO^® is a trademark of Merck KGaA, Darmstadt, Germany.
3dGRO^® organoids were derived utilizing HUB Organoid Technology.

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/pdouse. This product may not be re-engineered or copied; used to make derivatives or modifications; used to develop, test, or manufacture a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact [email protected].

3dGRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable