This antibody recognizes both the soluble and membrane bound human IL-6 receptor. The antibody will inhibit IL-6 mediated proliferation of XG-1 cells and partially blocks the binding of IL-6 to its receptor.
Immunogen
CHO cells transfected with a cDNA of the human IL-6 receptor.
Application
Flow cytometry: 1:50. Use 10 μL of this dilution to label 10e6 cells in 100 μL.
Immunohistochemistry on frozen sections.
Immunoprecipitation.
ELISA
Optimal working dilutions must be determined by the end user.
Research Category Inflammation & Immunology
Research Sub Category Immunoglobulins & Immunology
This Anti-CD126 Antibody, clone B-R6 is validated for use in ELISA, FC, IP, IH for the detection of CD126.
Physical form
Format: Purified
The monoclonal was purified by ion exchange chromatography and is presented as a liquid in phosphate buffered saline, pH 7.4, containing 0.09% sodium azide.
Storage and Stability
Maintain at 2°-8°C for up to 12 months from date of receipt in undiluted aliquots.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Molecular and cellular biology, 37(11) (2017-03-08)
Interleukin-6 (IL-6) is a multifunctional cytokine with important functions in various physiologic processes. Mice lacking IL-6 exhibit multiple phenotypic abnormalities, such as an inadequate immune and acute-phase response, and elevated levels of circulating IL-6 have been found to accompany several
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