ABC41-M
Anti-Mitofusin-1 Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
Fzo homolog, Transmembrane GTPase MFN1, Mitofusion-1
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 μg | Estimated to ship onApril 21, 2026fromKuehne + Nagel Sp. z o.o. | PLN 1,860.00 |
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, rat, mouse
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
target post-translational modification
unmodified
Gene Information
human ... MFN1(55669)
General description
Along with Mitofusin-2 (Mfn2), Mitofusin-1 (Mfn1) is a known protein mediator of mitochondrial fusion. Mitochondrial fusion regulates mitochondrial morphogensis and supports complementation between mitochondrial genomes in mammalian cells. Two Mfn1 transcripts are detected at similar levels in a variety of human tissues and are dramatically elevated in the heart. Human Mfn1 is known to be localized in the mitochondria. It is reported that point mutations in the conserved G1 and G2 region of the Mfn1 GTPase domain result in decreased formation and fragmentation of the mitochondria, respectively.
~86 kDa observed.
Three isoforms of Mitofusin-1 are produced by alternative splicing with molecular weights of ~42 kDa, ~71 kDa, and ~84 kDa Uncharacterized bands may appear at ~45 kDa, ~48 kDa, and ~55 kDa in some lysates.
Three isoforms of Mitofusin-1 are produced by alternative splicing with molecular weights of ~42 kDa, ~71 kDa, and ~84 kDa Uncharacterized bands may appear at ~45 kDa, ~48 kDa, and ~55 kDa in some lysates.
Immunogen
Epitope: Cytoplasmic Domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Mitofusin-1.
Application
Detect Mitofusin-1 using this Anti-Mitofusin-1 Antibody validated for use in WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Organelle & Cell Markers
Organelle & Cell Markers
Biochem/physiol Actions
This antibody recognizes Mitofusin-1 at the cytoplasmic domain.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
HeLa cell lysate
HeLa cell lysate
Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitofusin-1 in 10 µg HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitofusin-1 in 10 µg HeLa cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| biological source rabbit | biological source rabbit | biological source rabbit | biological source mouse |
| conjugate unconjugated | conjugate unconjugated | conjugate - | conjugate unconjugated |
| antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form - | antibody form purified immunoglobulin |
| Quality Level 100 | Quality Level 100 | Quality Level 300 | Quality Level 100 |
| Gene Information human ... MFN1(55669) | Gene Information human ... MFN2(9927) | Gene Information - | Gene Information human ... MFN1(55669) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. |
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Hypoxia induced upregulation and function of the thiamine transporter, SLC19A3 in a breast cancer cell line.
Rebecca Sweet,Amber Paul,Jason Zastre
Cancer Biology & Therapy null
Daniel Chauss et al.
G3 (Bethesda, Md.), 4(8), 1515-1527 (2014-06-15)
The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens. The lens epithelium overlies a core of terminally differentiated
Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice.
Panes, et al.
Cells, 12 (2023)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| ABC41 | 04053252293771 |