Caspase-1 (ICE, interleukin-1b-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1b and IL-18 into active cytokines. Like other caspases, caspase-1 itself is synthesized as a proenzyme that is cleaved during activation into large (20 kDa) and small (10 kDa) subunits.
Specificity
AB1871 recognizes the 45 kDa procaspase-1 as well as the 20 kDa cleaved caspase-1.
Application
This Anti-Caspase 1 Antibody is validated for use in IF, IP, WB for the detection of Caspase 1.
Western blot: 1-4 μg/mL
Immunoprecipitation: 4-8 μg/mL
Immunofluorescence: 10-20 μg/mL
Optimal working dilutions must be determined by end user.
Physical form
Affinity purified immunoglobulin. Liquid in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.
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