8.52308

Fmoc-hGlu(OtBu)-OH

Novabiochem^®

• Synonym(s): Fmoc-hGlu(OtBu)-OH, Fmoc-L-α-homoglutamic acid 6-t-butyl ester,(S)-2-(Fmoc-amino)adipic acid 6-t-butyl ester
• Empirical Formula (Hill Notation): C₂₅H₂₉NO₆
• CAS Number: 159751-47-0
• Molecular Weight: 439.50
• MDL number: MFCD00237006
• UNSPSC Code: 12352209

Properties

• Quality Segment: 200
• product line: Novabiochem^®
• form: solid
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 108-112 °C
• application(s): peptide synthesis
• functional group: carboxylic acid
• storage temp.: 2-8°C
• SMILES string: N([C@@H](CCCC(=O)OC(C)(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C25H29NO6/c1-25(2,3)32-22(27)14-8-13-21(23(28)29)26-24(30)31-15-20-18-11-6-4-9-16(18)17-10-5-7-12-19(17)20/h4-7,9-12,20-21H,8,13-15H2,1-3H3,(H,26,30)(H,28,29)/t21-/m0/s1
• InChI key: FFLAQPKWVSSKJC-NRFANRHFSA-N

Description

General description

A useful homolog of glutamic acid for the study of protein-protein interactions, tumor targeting, and SAR studies ^[1,2].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] R. Carpenter, et al. (2007) J. Med. Chem., 23, 5863.
^[2] P. Li, et al. (2006) Nat. Chem. Biol., 7, 381.

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable