645900

Triptolide, Tripterygium wilfordii

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

• Synonym(s): Triptolide, Tripterygium wilfordii, PG490
• Empirical Formula (Hill Notation): C₂₀H₂₄O₆
• CAS Number: 38748-32-2
• Molecular Weight: 360.40
• MDL number: MFCD00210565
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 20 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
• InChI key: DFBIRQPKNDILPW-CIVMWXNOSA-N

Description

General description

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activate DEVD-cleaving caspases

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Other Notes

Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology40, 139.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300 + H330,H361f
• Precautionary Statements: P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable