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RNA Polymerase III Inhibitor

Name: RNA Polymerase III Inhibitor
Brand: MM
Price: 1990 PLN
Availability: InStock

RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀= 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).

Synonym(s):

RNA Polymerase III Inhibitor, ML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide

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Pack Size	SKU	Availability	Price
10 mg		Available to ship TODAYfromKuehne + Nagel Sp. z o.o.	PLN 1,990.00

About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₅Cl₂N₃O₂S₂

CAS Number:

577784-91-9

Molecular Weight:

452.38

MDL number:

MFCD00112663

UNSPSC Code:

12352200

NACRES:

NA.54

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

PLN 1,990.00

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Properties

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 15 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(Nc2[n](nc(c2)c3[s]c4c(c3C)cc(cc4)Cl)C)c1c(cccc1)Cl

InChI

1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3

InChI key

BVBDTTLISMIOJY-UHFFFAOYSA-N

Description

General description

A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
activity against RNA Polymerase III

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 27 and 32 µM for Human and S. cerevisiae RNA Pol III

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Slight warming may be necessary to achieve complete solubilization.

Other Notes

Wu, L., et al. 2003. Euk. Cell2, 256.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

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This Item	361555	217714	420143
Sigma-Aldrich 557403 RNA Polymerase III Inhibitor	Sigma-Aldrich 361555 GSK-3 Inhibitor XIII	Sigma-Aldrich 217714 Cdk1/2 Inhibitor III	Sigma-Aldrich 420143 JNK3 Inhibitor XII, SR-3576
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
form solid	form solid	form solid	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKU	GTIN
557403-10MG	04055977268058

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