528240

Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets

• NACRES: NA.25
• UNSPSC Code: 12352202
• Form: liquid

Properties

• form: liquid
• Quality Level: 100
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• shipped in: wet ice
• storage temp.: −70°C

Description

General description

Native, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds to fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl₂, 50% glycerol, ≤0.1% sodium azide, pH 7.4.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Schwarz M., et al. 2004. J. Pharmacol. Exp. Therap.308, 1002.
Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• signalword: Danger
• hcodes: EUH430
• pcodes: P201 - P202 - P273 - P391 - P405 - P501
• Hazard Classifications: ED ENV 1