528118

PI 3-Kδ Inhibitor X, IC87114

The PI 3-Kδ Inhibitor X, IC87114, also referenced under CAS 371242-69-2, controls the biological activity of PI 3-Kδ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): PI 3-Kδ Inhibitor X, IC87114, Phosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X
• Empirical Formula (Hill Notation): C₂₂H₁₉N₇O
• CAS Number: 371242-69-2
• Molecular Weight: 397.43
• MDL number: MFCD09970845
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: OK to freeze

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [n]4(c5ncnc(c5nc4)N)Cc1[n]([c](c3c(n1)cccc3C)=O)c2c(cccc2)C
• InChI: 1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)
• InChI key: GNWHRHGTIBRNSM-UHFFFAOYSA-N

Description

General description

A cell permeable, selective inhibitor of PI 3-Kδ (IC₅₀= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Billottet, C., et al. 2009. Cancer Res.69,1027.
Ali, K., et al. 2008. J. Immunol.180, 2538.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable