528105

Picrotoxin, Anamirta cocculin

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system.

• Synonym(s): Picrotoxin, Anamirta cocculin
• Empirical Formula (Hill Notation): C₁₅H₁₈O₇ · C₁₅H₁₆O₆
• CAS Number: 124-87-8
• Molecular Weight: 602.58
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00074824
• Assay: ≥94% (mixture of Picrotoxin and picrotin, HPLC)
• Form: crystals, powder
• Storage condition: OK to freeze

Properties

• Quality Segment: 100
• description: Merck USA index - 14, 7415
• assay: ≥94% (mixture of Picrotoxin and picrotin, HPLC)
• form: crystals, powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to light yellow
• solubility: aqueous base: 3 mg/mL, ethanol: 50 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: O6[C@]87[C@H]6C[C@@]9([C@]8([C@H](OC7=O)C%10OC(=O)C9[C@@H]%10C(O)(C)C)C)O.O1[C@]32[C@@]4([C@H](OC3=O)C5OC(=O)C([C@@]4(CC21)O)[C@@H]5C(=C)C)C
• InChI: 1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1
• InChI key: VJKUPQSHOVKBCO-ZTYBEOBUSA-N

Description

General description

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^– channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

Biochem/physiol Actions

Primary Target
GABA receptors

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 240 nM against GABA receptors

Cell permeable: no

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol.464, 423.
Akaike, N., et al. 1985. Experientia41, 70.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable