5.08015

CTOP

• Synonym(s): CTOP, µ Opioid Receptor Antagonist, CTOP
• Empirical Formula (Hill Notation): C₅₀H₆₇N₁₁O₁₁S₂
• CAS Number: 103429-31-8
• Molecular Weight: 1062.26
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00076708
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• assay: ≥95% (HPLC)
• Quality Segment: 100
• form: solid
• potency: 0.96 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: water: soluble
• storage temp.: −20°C
• SMILES string: S1SCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1(C)C)C(=O)NC(C(O)C)C(=O)N)C(O)C)CCCN)Cc4c5c([nH]c4)cccc5)Cc3ccc(cc3)O)NC(=O)C(N)Cc2ccccc2
• InChI: 1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
• InChI key: PZWWYAHWHHNCHO-UHFFFAOYSA-N

Description

General description

A potent antagonist highly selective for µ opioid receptor (K_i = 0.96 nM for µ receptor and >10,000 nM for δ receptors). Often used for studying the functional roles of µ opioid receptors in both central and peripheral nervous systems.

Biochem/physiol Actions

Primary Target
mu opioid

Physical form

Supplied as trifluoracetate salt

Other Notes

D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Orn: ornithine; Pen: penicillamine; SS bond: 2-7)

Feng, Y., et al. 2012. Curr Drug Targets.13, 230.
Hawkins, N., et al. 1989. J. Pharmacol. Exp. Ther.248, 73.
Gulya, K., et al. 1988. Eur. J. Pharmacol.150, 355.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable