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444290

MMP Inhibitor V

The MMP Inhibitor V, also referenced under CAS 223472-31-9, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

MMP Inhibitor V, (2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817

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Size/SKUAvailabilityPrice
2 mg

Estimated to ship onJune 03, 2026fromKuehne + Nagel Sp. z o.o.

PLN 650.00

About This Item

Empirical Formula (Hill Notation):
C22H28N2O6
CAS Number:
223472-31-9
Molecular Weight:
416.47
MDL number:
MFCD09971106
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light

PLN 650.00

Estimated to ship onJune 03, 2026Details

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Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

ethanol: 15 mg/mL, DMSO: 30 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

N(O)C(=O)[C@H](C[C@H](NC(=O)c1ccc(cc1)Oc2ccccc2)COCOCC)C

InChI

1S/C22H28N2O6/c1-3-28-15-29-14-18(13-16(2)21(25)24-27)23-22(26)17-9-11-20(12-10-17)30-19-7-5-4-6-8-19/h4-12,16,18,27H,3,13-15H2,1-2H3,(H,23,26)(H,24,25)/t16-,18-/m0/s1

InChI key

HDWWQELUBWGQGA-WMZOPIPTSA-N

General description

An orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2, -3, -8, -9, -12, -13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.

Packaging

Packaged under inert gas

Other Notes

Okamoto, Y., et al. 2007. Int. Heart J.48, 369.
Ito, N., et al. 2004. Biochem. Biophys. Res. Commun.314, 1008.
Shiraga, M., et al. 2002. Cancer Res.62, 5967.
Mori, T., et al. 2001. Exp. Biol. Med.226, 429.
Yamada, A., et al. 2000. Inflamm. Res.49, 144.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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MMP Inhibitor V The MMP Inhibitor V, also referenced under CAS 223472-31-9, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444290

MMP Inhibitor V

MMP-9/MMP-13 Inhibitor I The MMP-9/MMP-13 Inhibitor I, also referenced under CAS 204140-01-2, controls the biological activity of MMP-9/MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Millipore

444252

MMP-9/MMP-13 Inhibitor I

MMP-2/MMP-3 Inhibitor III, PD166793 The MMP-2/MMP-3 Inhibitor III, PD166793, also referenced under CAS 199850-67-4, controls the biological activity of MMP-2/MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444284

MMP-2/MMP-3 Inhibitor III, PD166793

MMP-2 Inhibitor III The MMP-2 Inhibitor III, also referenced under CAS 704888-90-4, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444288

MMP-2 Inhibitor III

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (TLC)

assay

≥95% (HPLC)

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

ethanol: 15 mg/mL, DMSO: 30 mg/mL

solubility

methanol: 1 mg/mL, DMSO: 100 mg/mL

solubility

DMSO: 40 mg/mL, ethanol: 40 mg/mL

solubility

methanol: 100 mg/mL, DMSO: 200 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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