218728

Caspase-9 Inhibitor III

The Caspase-9 Inhibitor III, also referenced under CAS 403848-57-7, controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): Caspase-9 Inhibitor III, Ac-LEHD-CMK
• Empirical Formula (Hill Notation): C₂₄H₃₅ClN₆O₉
• CAS Number: 403848-57-7
• Molecular Weight: 587.02
• MDL number: MFCD02259690
• UNSPSC Code: 12352200
• NACRES: NA.54
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white
• solubility: water: 1 mg/mL, DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: ClCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CCC(=O)O)Cc1nc[nH]c1)CC(=O)O
• InChI: 1S/C24H35ClN6O9/c1-12(2)6-17(28-13(3)32)23(39)29-15(4-5-20(34)35)22(38)31-18(7-14-10-26-11-27-14)24(40)30-16(8-21(36)37)19(33)9-25/h10-12,15-18H,4-9H2,1-3H3,(H,26,27)(H,28,32)(H,29,39)(H,30,40)(H,31,38)(H,34,35)(H,36,37)/t15-,16-,17-,18-/m0/s1
• InChI key: JSRLQUNMFYXVQD-XSLAGTTESA-N

Description

General description

A potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).

A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-9

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 70 nM against caspase-9

Other Notes

Ac-Leu-Glu-His-Asp-CMK

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable