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Anti-SREBP1 Antibody, clone 2121

Name: Anti-SREBP1 Antibody, clone 2121
Brand: MM
Price: 773 PLN
Availability: InStock

clone 2121, Upstate^®, from mouse

Synonym(s):

SREBF1, sterol regulatory element binding transcription factor 1

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Pack Size	SKU	Availability	Price
25 μL		Estimated to ship TODAYfromKuehne + Nagel Sp. z o.o.	PLN 773.00
100 μL		Estimated to ship TODAYfromKuehne + Nagel Sp. z o.o.	PLN 1,910.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

2121, monoclonal

Application:

Citations:

PLN 773.00

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Properties

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

2121, monoclonal

species reactivity

human

packaging

antibody small pack of 25 μL

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG1

NCBI accession no.

NM_001005291.1, NM_004176.3

UniProt accession no.

P36956

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SREBF1(6720)

Description

General description

126 kDa

Immunogen

Recombinant His-tagged human SREBP-1a protein encompassing amino acids 301-407.

Application

Anti-SREBP1 Antibody, clone 2121 is a Mouse Monoclonal Antibody for detection of SREBP1 also known as sterol regulatory element binding transcription factor 1 & has been validated in WB.

Biochem/physiol Actions

Reacts with the basic helix-loop-helix leucine zipper (bHLH-ZIP) of SREBP.

Physical form

100 μL (1 mg/mL) of protein A purified mouse monoclonal IgG1 in PBS with 0.1% sodium azide.

Format: Purified

Preparation Note

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

Analysis Note

Routinely evaluated by immunoblot.

Other Notes

feature_concentration_valuePlease refer to lot specific datasheet.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Show Differences

1 of 1

This Item	MABS2034	ABS1508	MABS1988
Sigma-Aldrich 04-469 Anti-SREBP1 Antibody, clone 2121	Sigma-Aldrich MABS2034 Anti-SREBP-1 Antibody, clone 2A4	Sigma-Aldrich ABS1508 Anti-SREBP-1	Sigma-Aldrich MABS1988 Anti-SREBP-2 Antibody, clone 22D5
biological source mouse	biological source mouse	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone 2121, monoclonal	clone 2A4, monoclonal	clone polyclonal	clone 22D5, monoclonal
species reactivity human	species reactivity hamster, canine, human	species reactivity human	species reactivity mouse, human
antibody form purified antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form unpurified
shipped in dry ice	shipped in -	shipped in ambient	shipped in ambient

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding.

Tanel Punga et al.

The Journal of biological chemistry, 281(35), 25278-25286 (2006-07-11)

Members of the sterol regulatory element-binding protein (SREBP) family of transcription factors control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation. The transcription factor SREBP1 is degraded by the ubiquitin-proteasome system following phosphorylation of Thr426 and Ser430

N-arachidonoyl dopamine inhibits epithelial-mesenchymal transition of breast cancer cells through ERK signaling and decreasing the cellular cholesterol.

Shreetama Bandyopadhayaya et al.

Journal of biochemical and molecular toxicology, 35(4), e22693-e22693 (2021-01-05)

N-acyl dopamines (NADAs) are bioactive lipids of the endovanilloid family with known cytotoxicity for the cancer cells; however, the available data on the participation of the endovanilloids in epithelial-mesenchymal transition (EMT) and cancer stemness are controversial. This study unveils the

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Amy K Walker et al.

Genes & development, 24(13), 1403-1417 (2010-07-03)

The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In mammals, SREBPs are highly active in the fed state to promote the expression of lipogenic and cholesterogenic genes and

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Global Trade Item Number

SKU	GTIN
04-469-25UL	04054839350122

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