800715P
Avanti
N-P Serine PA
Avanti Research™ - A Croda Brand 800715P, powder
Synonym(s):
N-palmitoyl-serine phosphoric acid (ammonium salt)
Sign Into View Organizational & Contract Pricing
Select a Size
1 MG
PLN 717.00
All Photos(1)
Select a Size
Change View
1 MG
PLN 717.00
About This Item
Empirical Formula (Hill Notation):
C19H44N3O7P
CAS Number:
Molecular Weight:
457.54
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (800715P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 800715P
lipid type
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
General description
Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid is a competitive inhibitor of the LPA receptor in Xenopus oocytes.[1][2] However, in mammalian cells, N-palmitoyl-serine phosphoric acid may act as an agonist for the LPA receptor. [3][4] LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors.[1][2][3][4][5] LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation.[1] N-palmitoyl serine phosphoric acid may also play a role in signal transduction in mammalian cells by increasing intracellular calcium. [4][5]
N-palmitoyl serine phosphoric acid prevents human platelet aggregation, which is induced by 1-hexadecyl-2-lyso-sn-glycero-3-phosphate.[6]
Packaging
5 mL Amber Glass Screw Cap Vial (800715P-1mg)
Preparation Note
Product use: A range of 0.1-20 mM of N-palmitoyl serine phosphoric acid can be used for cell studies. Make a stock solution of 5 mM in DMSO and store at -20°C. Diluted N-palmitoyl serine phosphoric acid can be directly added to the study medium. [5]An et al. dissolved N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells.[4] In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.[2]
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.
If you need assistance, please contact Customer Support.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids.
Bittman R, et al.
Journal of Lipid Research, 37(2), 391-398 (1996)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.
An, S
Molecular Pharmacology, 54, 881-888 (1998)
S B Hooks et al.
Molecular pharmacology, 53(2), 188-194 (1998-03-14)
Despite an intriguing cell biology and the suggestion of a role in pathophysiological responses, the mechanism of action of such lipid phosphoric acid mediators as lysophosphatidic acid (LPA) remains obscure, in part because of an underdeveloped medicinal chemistry. We report
K Liliom et al.
Molecular pharmacology, 50(3), 616-623 (1996-09-01)
Lysophosphatidic acid is the best characterized member of a lipid mediator family with growth factor-like activities that act through a class of G protein-coupled plasma membrane receptors. In Xenopus laevis oocytes, lysophosphatidate activates at least two pharmacologically distinct receptor subtypes
Characterization of a receptor subtype-selective lysophosphatidic acid mimetic
Hooks, S.B, et. al.
Molecular Pharmacology, 53, 188-194 (1998)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
