930652

Pomalidomide-C₂-NH₂ hydrochloride

≥95%

• Synonym(s): 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, E3 Ligase Ligand 17
• Empirical Formula (Hill Notation): C₁₅H₁₆N₄O₄ · xHCl
• CAS Number: 2305369-00-8
• Molecular Weight: 316.31 (free base basis)
• UNSPSC Code: 12352101
• NACRES: NA.21
• MDL number: MFCD31730839

Properties

• ligand: pomalidomide
• Quality Segment: 100
• assay: ≥95%
• form: powder
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCN)=CC=C3)=O)=O.Cl
• InChI: 1S/C15H16N4O4.ClH/c16-6-7-17-9-3-1-2-8-12(9)15(23)19(14(8)22)10-4-5-11(20)18-13(10)21;/h1-3,10,17H,4-7,16H2,(H,18,20,21);1H
• InChI key: DSJCOXQYDMWPEY-UHFFFAOYSA-N

Description

Application

Pomalidomide-C₂-NH₂ Hydrochloride is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with carboxyl linkers due to the presence of an amine group via peptide coupling reactions. It is also active for linker attachment via reductive amination, and a basic building block for development of a protein degrader library.


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation


Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable