Inhibition of recombinant mouse wild type AChE (EC 3.1.1.7) and BChE (EC 3.1.1.8), and AChE peripheral site-directed mutants and human serum BChE variants by 4,4'-bipyridine (4,4'-BP) and the coumarin derivative 3-chloro-7-hydroxy-4-methylcoumarin (CHMC) was studied. The enzyme activity was measured with
The biotransformation and disposition of 3-chloro-4-methyl-(4-14C)-7-hydroxycoumarin [(14C) chlorferron] were investigated in rats after single oral administration. Following administration of (14C) chlorferron at 0.5 and 20 mg/kg body weight to male rats, greater than 90% of the given dose was eliminated
Advances in experimental medicine and biology, 136 Pt A, 839-846 (1981-01-01)
The distribution, excretion and biotransformation of 3-chloro-4-methyl-(4-14C)-7-hydroxycoumarin [(14C) chlorferron] were studied in the rats after single oral administration. Male and female Wistar rats were given single oral doses of 0.5 and 20.0 mg/kg body weight of (14C) chlorferron and routes
Chlorferon and diethylthiophosphate (DETP) are the hydrolysis products of coumaphos, an organophosphate pesticide. In this research, two consortia of bacterial cultures, one responsible for degrading chlorferon and the other for degrading DETP, were selectively enriched from waste cattle dip solution.
Letters in applied microbiology, 34(4), 263-268 (2002-04-10)
To develop a simple, rapid and sensitive fluorimetric assay to detect, isolate and characterize a soil bacterium capable of degrading the organophosphorus pesticide, coumaphos. A high throughput microtitre plate-based method was used to quantify coumaphos hydrolysis by the bacterium. The
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