Biochimica et biophysica acta, 1772(1), 48-59 (2006-12-19)
Carcinogen-induced formation of DNA adducts and other types of DNA lesions are the critical molecular events in the initiation of chemical carcinogenesis and modulation of such events by chemopreventive agents could be an important step in limiting neoplastic transformation in
Vanadium and its derivatives are the well-known environmental pollutants. We obtained that ammonium vanadate suppressed the alkaline (AlP) and acid (AcP) phosphatases activity in the variety of tissues. Vanadate inhibited the enzymes that take part in phosphoryl transfer reactions. Successive
Metallothionein (MT) is a low-molecular-weight cysteine-rich protein which has a high affinity for metals. The synthesis of MT is induced by heavy metals such as cadmium and zinc. However, little is known about the induction of MT by tetravalent or
Transitional metals, as vanadium, are known to exert noxious effects by generating oxidative stress. Addition of antioxidants in the diet could decrease the cytotoxic effect related to the oxidative stress. The present study, carried out in Wistar rats, is a
Vanadium is a ubiquitous trace metal present in most plant and animal tissues. Environmental exposure to trivalent and pentavalent inorganic vanadium compounds has been related to impaired different phases of reproduction. Therefore, the effects of a pentavalent inorganic vanadium compound
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