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A3253

Sigma-Aldrich

Ala-Pro hydrate

≥98% (TLC), suitable for ligand binding assays

Synonym(s):

L-Alanyl-L-proline hydrate

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About This Item

Empirical Formula (Hill Notation):
C8H14N2O3 · xH2O
CAS Number:
13485-59-1
Molecular Weight:
186.21 (anhydrous basis)
Beilstein:
3546017
EC Number:
236-795-8
MDL number:
MFCD00150505
UNSPSC Code:
12352202
PubChem Substance ID:
24890751
NACRES:
NA.26

product name

Ala-Pro hydrate,

Assay

≥98% (TLC)

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

O.C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C8H14N2O3.H2O/c1-5(9)7(11)10-4-2-3-6(10)8(12)13;/h5-6H,2-4,9H2,1H3,(H,12,13);1H2/t5-,6-;/m0./s1

InChI key

SSUWZOPYGFOQJA-GEMLJDPKSA-N

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Biochem/physiol Actions

Alanyl dipeptides such as ala-leu, ala-lys, ala-gly, ala-pro, ala-tyr and ala-phe may be used in physicochemical studies or to evaluate dipeptide separation technologies. Alanyl dipeptides may also be used for studying cell uptake mechanisms, dipeptide metabolism or cell growth supplementation benefits.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Justin F Shaffer et al.
Journal of muscle research and cell motility, 30(7-8), 303-306 (2010-03-11)
Cardiac myosin binding protein-C (cMyBP-C) is an accessory protein found in the A-bands of vertebrate sarcomeres and mutations in the cMyBP-C gene are a leading cause of familial hypertrophic cardiomyopathy. The regulatory functions of cMyBP-C have been attributed to the
Pekka Mark et al.
European biophysics journal : EBJ, 36(3), 213-224 (2007-01-17)
Six different molecular dynamics simulations of Cyclophilin A, three with the protein free in water and three with the Ala-Pro dipeptide bound to the protein, have been performed, and analysed with respect to structure and hydration of the active site.
M Sugawara et al.
The Journal of pharmacy and pharmacology, 46(8), 680-684 (1994-08-01)
The types of inhibitory effects caused by compound V (an analogue of ceftibuten) and alanylproline (dipeptide) on the uptake of ceftibuten by brush-border membrane vesicles (BBMV) prepared from human and rat small intestine were analysed. In the presence of an
H Ke et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(8), 3324-3328 (1993-04-15)
Cyclophilin is a binding protein for the immunosuppressive drug cyclosporin A and is also an enzyme with peptidyl-prolyl cis-trans isomerase activity. The crystal structure of cyclophilin A complexed with the substrate Ala-Pro has been determined and refined to an R
I Naasani et al.
Biochimica et biophysica acta, 1231(2), 163-168 (1995-09-12)
The transport characteristics of ceftibuten, a dianionic cephem antibiotic, in rat renal and intestinal brush-border membranes were compared. Ceftibuten transport was mediated by two transport systems in the renal brush-border membrane and by one transport system in the intestinal brush-border
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