X2254

XE-991

≥98% (HPLC), powder, KCNQ channel blocker

• Sinónimos: 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
• Fórmula empírica (notación de Hill): C₂₆H₂₀N₂O
• Número de CAS: 122955-42-4
• Peso molecular: 376.45
• Número MDL: MFCD05662331
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329830775
• NACRES: NA.77

Propiedades

• Nombre del producto: XE-991, ≥98% (HPLC)
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• color: white to beige
• solubilidad: DMSO: >20 mg/mL
• emisor: Merck & Co., Inc., Kenilworth, NJ, U.S.
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C1c2ccccc2C(Cc3ccncc3)(Cc4ccncc4)c5ccccc15
• InChI: 1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2
• Clave InChI: KHJFBUUFMUBONL-UHFFFAOYSA-N

Descripción

Aplicación

XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).

Acciones bioquímicas o fisiológicas

XE-991 is a KCNQ channel blocker.

XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).

Características y beneficios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable