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Merck

T3126

Sigma-Aldrich

DL-α-Tocopherol succinate

semisynthetic, 1210 IU/g

Sinónimos:

Vitamin E succinate

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About This Item

Fórmula empírica (notación de Hill):
C33H54O5
Número de CAS:
Peso molecular:
530.78
Beilstein/REAXYS Number:
4038233
EC Number:
MDL number:
UNSPSC Code:
12352205
eCl@ss:
34058016
PubChem Substance ID:
NACRES:
NA.28

biological source

semisynthetic

Quality Level

form

powder

specific activity

1210 IU/g

color

white to yellow

storage temp.

room temp

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1

InChI

1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1

InChI key

IELOKBJPULMYRW-NJQVLOCASA-N

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General description

α-Tocopherol succinate is a fat soluble vitamin. α-Tocopherol is a form of vitamin E, which can be obtained through dietary sources. RRR-α-tocopherol is a natural form of α-Tocopherol.

Application

D-α-Tocopherol succinate has been used:
  • to as a dietary supplement to study its immunomodulatory effects in chicks
  • as a dietary supplement in pregnant women to evaluate its effects on arsenic exposure
  • as an antioxidant to investigate concurrent pathways of cell death due to acute exercise

Biochem/physiol Actions

α-Tocopherol is also called as a radical-chain breaker due to its anti-oxidant property.
Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. α-Tocopherol succinate is used along the α-Tocopherol acetate, α-Tocopherol nicotinate and other esterified forms as a vitamin E supplement with similar but differential activities.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Maria F Arisi et al.
Physiological reports, 5(11) (2017-06-04)
Aerobic exercise confers many health benefits. However, numerous reports have shown that acute aerobic exercise can injure the heart. We tested the general hypothesis that acute moderate-intensity exercise in rodents induces cardiomyocyte damage and stimulates mesenchymal stem cells (MSCs) to
Wenbin Zhu et al.
PloS one, 9(3), e92992-e92992 (2014-03-26)
Benzo[a]pyrene (BaP), a well-known environmental carcinogen, promotes oxidative stress and DNA damage. Curcumin and vitamin E (VE) have potent antioxidative activity that protects cells from oxidative stress and cellular damage. The objectives of the present study were to investigate the
Effects of immunomodulatory nutrients on growth performance and immune-related gene expression in layer chicks challenged with lipopolysaccharide
Wils-Plotz EL and Klasing KC
Poultry Science, 96(3), 548-555 (2017)
Tocopherols, tocotrienols and tocomonoenols: Many similar molecules but only one vitamin E
Azzi A
Redox Biology, 101259-101259 (2019)
Cong-Jun Li et al.
Gene regulation and systems biology, 6, 1-14 (2012-01-24)
To further investigate the potential role of α-tocopherol in maintaining immuno-homeostasis in bovine cells (Madin-Darby bovine kidney epithelial cell line), we undertook in vitro experiments using recombinant TNF-α as an immuno-stimulant to simulate inflammation response in cells with or without

Artículos

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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