SML3233
GlucoseCy5
≥98% (HPLC)
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About This Item
Fórmula empírica (notación de Hill):
C38H50N3O6Cl
Número de CAS:
Peso molecular:
680.27
UNSPSC Code:
12352107
NACRES:
NA.77
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Quality Level
assay
≥98% (HPLC)
form
powder
color
blue to black
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
General description
GlucoseCy5 is a cell-permeable, Cy5-linked 1-amino-1-deoxy-β-glucose fluorescent tracer. It is used for glucose transporter (GLUT)-mediated molecular sensing and bioimaging. GlucoseCy5 demonstrates superior specificity, sensitivity, and non-toxicity over 2-NBDG. λ emission & excitation ~ 644 nm & 665 nm. Suggested optimum concentration and incubation for cellular uptake: 50 μM & 20 min.
Application
GlucoseCy5 has been used as a component in serum-free Dulbecco′s modified eagle medium (DMEM) for fluorescence-activated cell sorting (FACS) and glucose-uptake assay.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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Hu Xu et al.
Biochemical and biophysical research communications, 474(2), 240-246 (2016-04-02)
Two novel cyanine-based 1-amino-1-deoxy-β-glucose conjugates (Glu-1N-Cy3 and Glu-1N-Cy5) were designed, synthesized and their fluorescence characteristics were studied. Both Glu-1N-Cy3 and Glu-1N-Cy5 accumulate in living HT29 human colon cancer cells, which overexpress glucose transporters (GLUTs). The cellular uptake of the bioprobes
Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
Zhang X, et al.
Cell Reports (2023)
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
Watson MJ, et al.
Nature (2021)
McLane J Watson et al.
Nature, 591(7851), 645-651 (2021-02-17)
Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the recruitment, differentiation and activity of these cells1,2. Tumour cells show deregulated metabolism, leading to a metabolite-depleted
Xiangyin Liu et al.
Biochemical and biophysical research communications, 480(3), 341-347 (2016-10-26)
Two novel fluorescent bioprobes, namely, 6N-Gly-Cy3 and 6N-Gly-Cy5, were designed and synthesized for real-time glucose transport imaging as well as potentially useful tracer for galactokinase metabolism. The structure of the bioprobes was fully characterized by 1H NMR, 13C NMR, IR
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