Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

Ver Toda la documentación

SML2090

Sigma-Aldrich

NAMI-A

≥98% ruthenium (Ru) basis (elemental analysis)

Sinónimos:

1H-Imidazole (OC-6-11)-tetrachloro(1H-imidazole-κN3)[1,1′-(sulfinyl-κS)bis[methane]]ruthenate(1-) (1:1), ImH[trans-RuCl4(DMSO)Im], Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C5H10Cl4N2ORuS · C3H5N2
Número de CAS:
201653-76-1
Peso molecular:
458.18
Código UNSPSC:
12352200
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Ensayo

≥98% ruthenium (Ru) basis (elemental analysis)

Formulario

powder

condiciones de almacenamiento

desiccated

color

faint red to dark brown

solubilidad

H2O: 2 mg/mL, clear

temp. de almacenamiento

−20°C

cadena SMILES

CS(C)=O.Cl[Ru](Cl)(Cl)Cl.N1=CNC=C1.C2=[NH+]C=CN2

Clave InChI

HIAWXYSWERGOAJ-UHFFFAOYSA-K

Acciones bioquímicas o fisiológicas

NAMI-A is a potent antimetastatic drug in vivo that is exhibits little cytotoxicity towards many cancer cell lines. Antimetastatic of NAMI-A is attributed to the formation of adducts with membrane and cytosolic proteins. Nevertheless NAMI-A induces potent and selective cytotoxic effects in several leukemia cell lines. NAMI-A exhibits low toxicity for host tissues.
NAMI-A is a ruthenium-based anticancer agent.[1]
potent antimetastatic drug

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documentos section.

Si necesita más asistencia, póngase en contacto con Atención al cliente

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Serena Pillozzi et al.
Dalton transactions (Cambridge, England : 2003), 43(32), 12150-12155 (2014-07-01)
We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic"
Alberta Bergamo et al.
Journal of inorganic biochemistry, 168, 90-97 (2017-01-09)
Solid tumours are constituted of tumour cells, healthy cells recruited from the host tissues and soluble factors released by both these cell types. The present investigation examines the capacity of co-cultures between the HCEC colon epithelial cells and the HCT-116
K Śpiewak et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(4), 695-703 (2015-03-21)
Imidazolium trans-tetrachloridodimethylsulfoxideimidazolruthenate(III), NAMI-A, a novel antimetastatic ruthenium complex was investigated towards affinity to transferrin (Tf), whether Tf-Ru adducts might be formed after its intravenous injection. Studies were focused on the holotransferrin due to its preferential binding to transferrin receptor. Here
Metal-DNA coordination complexes
Pizarro AM, et al.
3D printing and additive manufacturing (2013)

Questions

Reviews

No rating value

Active Filters

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico