SAB4200668

Anti-Chromogranin A antibody produced in rabbit

affinity isolated antibody

• Sinónimos: CGA, CHGA, chromogranin A (parathyroid secretory protein 1)
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• Formulario: buffered aqueous solution
• reactividad de especies: human
• concentración: ~1 mg/mL
• técnicas: immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas sections
• Nº de acceso UniProt: P10645
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CHGA(1113)

Descripción

Descripción general

CHGA (chromogranin A) is a granin family acidic glycoprotein. It resides in endocrine and neuroendocrine cells, where it is localized to secretory dense-core granules which store peptide hormones. It is a predominant protein of the chromaffin cell secretory granules.

Inmunógeno

synthetic peptide corresponding to the GR-44 peptide in the C-terminal region of human Chromogranin-A , conjugated to KLH.

Aplicación

Anti-Chromogranin A antibody produced in rabbit has been used in immunohistochemistry.

Acciones bioquímicas o fisiológicas

CHGA (chromogranin A) is secreted in abnormal levels by neoplastic neuroendocrine cells, which might be linked with tumor growth and progression, as it might influence the different components of tumor stroma. It is a highly sensitive and specific biomarker for the diagnosis of NETs (neuroendocrine tumors). CHGA is processed to produce catestatin (CST), vasostatin-I, serpinin and pancreastatin (PST), which function as metabolic or cardiovascular-regulatory peptides. As this protein is co-stored and co-released with catecholamines, it plays an essential role in production of catecholamine storage vesicles. It functions as a circulating biomarker for gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) patients.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable