SAB2700730

Monoclonal Anti-TET1 antibody produced in mouse

clone GT1462, affinity isolated antibody, buffered aqueous solution

• Sinónimos: CXXC6, FLJ10839, FLJ41442, TET1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: GT1462, monoclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human, mouse
• técnicas: ChIP: suitable; immunofluorescence: suitable; immunohistochemistry: 1:100-1:1000; immunoprecipitation (IP): suitable; western blot: 500-3000
• isotipo: IgG2
• Nº de acceso NCBI: NP_085128
• Nº de acceso UniProt: Q8NFU7
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TET1(80312)

Descripción

Descripción general

Tet methylcytosine dioxygenase 1 (TET1) is a protein that belongs to the TET family and contains a zinc-binding CXXC domain. It is expressed in embryonic stem cells. The TET1 gene is localized on human chromosome 10q21.3.

Aplicación

Recombinant protein encompassing a sequence within the center region of human TET1. The exact sequence is proprietary.

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, IP: 1:100-1:500, WB: 1:500-1:3000, ChIP assay: Assay-dependent dilution. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Acciones bioquímicas o fisiológicas

Tet methylcytosine dioxygenase 1 (TET1) functions as a 5-methylcytosine (5mC) hydroxylase. It converts 5-methylcytosine to 5-hydroxymethylcytosine, which is crucial for active DNA demethylation in the adult brain. The protein has been linked to the progression of colorectal cancer.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Phosphate-buffered saline, no preservative added.

Almacenamiento y estabilidad

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Otras notas

For in vitro laboratory use only. Not for any clinical, therapeutic or diagnostic use in humans or animals. Not for animal or human consumption.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H317,H412
• Consejos de prudencia: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Clasificaciones de peligro: Aquatic Chronic 3 - Skin Sens. 1
• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable