R8657

Razoxane

>98% (HPLC)

• Sinónimos: (±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, (±)-1,2-Bis(3,5-dioxopiperazinyl)propane, 1,2-Bis(3,5-dioxo-1-piperazinyl)propane, 4,4′-Propylenebis(2,6-piperazinedione), ICI 59118, ICRF 159, NSC 129943, Razoxin, Tepirone, Troxozone
• Fórmula empírica (notación de Hill): C₁₁H₁₆N₄O₄
• Número de CAS: 21416-67-1
• Peso molecular: 268.27
• Número CE: 244-379-2
• Número MDL: MFCD00430424
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329824039
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: >98% (HPLC)
• Formulario: solid
• solubilidad: DMSO: 40 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
• InChI: 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)
• Clave InChI: BMKDZUISNHGIBY-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

Razoxane is clinically active against angiogenesis and metastasis; inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable