PZ0374

PF-06446846 hydrochloride

≥98% (HPLC)

• Sinónimos: N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
• Fórmula empírica (notación de Hill): C₂₂H₂₀ClN₇O · xHCl
• Número de CAS: 1632250-50-0
• Peso molecular: 433.89 (free base basis)
• UNSPSC Code: 41121800
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -60 to -50°, c = 1 in methanol
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: room temp
• SMILES string: O=C(C1=CC=C(N2C(N=CC=C3)=C3N=N2)C=C1)N([C@H]4CNCCC4)C5=C(Cl)C=CC=N5
• InChI: 1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1
• InChI key: FDTXHWQFIXYHCL-QGZVFWFLSA-N

Descripción

Biochem/physiol Actions

PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3