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P8692

Sigma-Aldrich

Paromomycin sulfate salt

powder, suitable for plant cell culture, BioReagent

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About This Item

Fórmula empírica (notación de Hill):
C23H45N5O14 · xH2SO4
Número de CAS:
1263-89-4
Peso molecular:
615.63 (free base basis)
Beilstein:
5715182
Código UNSPSC:
10171502
ID de la sustancia en PubChem:
24898967
NACRES:
NA.72
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Paromomycin sulfate salt, suitable for plant cell culture, BioReagent

Línea del producto

BioReagent

Nivel de calidad

200

Formulario

powder

técnicas

cell culture | plant: suitable

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria

aplicaciones

agriculture

Modo de acción

protein synthesis | interferes

cadena SMILES

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

Clave InChI

OYJABWUHUYVDMJ-UDXJMMFXSA-N

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Descripción general

Chemical structure: aminoglycoside

Aplicación

Paromomycin, monomycin, is an aminoglycoside antibiotic used to select genetically transformed plants and plant cells.

Acciones bioquímicas o fisiológicas

Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, some protozoan species, and limited antihelminth.
Mode of Action: Inhibits initiation and elongation during protein synthesis.
Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Envase

5g,25g

Otras notas

Keep container tightly closed in a dry and well-ventilated place

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000388236
0000354962
0000354962
0000401238
0000388236

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In eukaryotes, the tRNA-mimicking polypeptide-chain release factor, eRF1, decodes stop codons on the ribosome in a complex with eRF3; this complex exhibits striking structural similarity to the tRNA-eEF1A-GTP complex. Although amino acid residues or motifs of eRF1 that are critical
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During sexual reproduction in the ciliate, Tetrahymena thermophila, cells of complementary mating type pair ("conjugate") undergo simultaneous meiosis and fertilize each other. In both mating partners only one of the four meiotic products is "selected" to escape autophagy, and this
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PLoS neglected tropical diseases, 6(5), e1657-e1657 (2012-05-26)
With widespread resistance to antimonials in Visceral Leishmaniasis (VL) in the Indian subcontinent, Miltefosine (MIL) has been introduced as the first line therapy. Surveillance of MIL susceptibility in natural populations of Leishmania donovani is vital to preserve it and support
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PLoS neglected tropical diseases, 6(5), e1664-e1664 (2012-06-06)
Paromomycin (PMM) has recently been introduced for treatment of visceral leishmaniasis in India. Although no clinical resistance has yet been reported, proactive vigilance should be warranted. The present in vitro study compared the outcome and stability of experimental PMM-resistance induction
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Alternative treatments for visceral leishmaniasis (VL) are required in East Africa. Paromomycin sulphate (PM) has been shown to be efficacious for VL treatment in India. A multi-centre randomized-controlled trial (RCT) to compare efficacy and safety of PM (20 mg/kg/day for
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