P1499

Pterostilbene

≥97% (HPLC), solid

• Sinónimos: Pterocarpus marsupium, 3,5-Dimethoxy-4′-hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol
• Fórmula empírica (notación de Hill): C₁₆H₁₆O₃
• Número de CAS: 537-42-8
• Peso molecular: 256.30
• Número MDL: MFCD00238710
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24724573
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (HPLC)
• Formulario: solid
• condiciones de almacenamiento: protect from light
• solubilidad: DMSO: >20 mg/mL; H₂O: insoluble
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1
• InChI: 1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
• Clave InChI: VLEUZFDZJKSGMX-ONEGZZNKSA-N

Descripción

Descripción general

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene), an antioxidant is an analogue of resveratrol. It is present in blueberries, tree wood and some types of grapes.

Aplicación

Pterostilbene has been used:

• to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway
• to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)
• to study its effects on the cytotoxicity of 2-chloroethyl ethyl sulphide (CEES) in human epidermoid carcinoma cells (A-431) through MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide)viability assay

Acciones bioquímicas o fisiológicas

Antioxidant, antiproliferative, apoptosis inducer, antihyperglycemic, antidiabetic.

Pterostilbene exhibits antineoplastic properties in some of the malignancies, hence it is considered as an active anticancer agent. It has the ability to stimulate apoptosis and block the viability of cell in estrogen-receptor positive and negative breast cancer cell lines.

Precaución

Air-sensitive

Información de seguridad

• Pictogramas: GHS05,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H318,H411
• Consejos de prudencia: P273 - P280 - P305 + P351 + P338 + P310
• Clasificaciones de peligro: Aquatic Chronic 2 - Eye Dam. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves