M7317

Monoclonal Anti-MDR3 P-Glycoprotein antibody produced in mouse

250 μg/mL, clone P₃II-26, tissue culture supernatant

• Sinónimos: Anti-ABC21, Anti-GBD1, Anti-ICP3, Anti-MDR2, Anti-MDR2/3, Anti-MDR3, Anti-PFIC-3, Anti-PGY3
• Número MDL: MFCD03791722
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: tissue culture supernatant
• tipo de anticuerpo: primary antibodies
• clon: P₃II-26, monoclonal
• reactividad de especies: human
• concentración: 250 μg/mL
• técnicas: immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (not suitable for human tissues); immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections; western blot: suitable
• isotipo: IgG2b
• Nº de acceso UniProt: P21439
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ABCB11(8647) , ABCB4(5244)

Descripción

Descripción general

Multidrug resistance protein 3 (MDR3) is also known as ATP binding cassette subfamily B member 4. It is expressed in hepatocytes and made up of 1279 amino acids. The gene encoding it is localized on human chromosome 7q21.12 and consists of 27 exons.

Especificidad

Reacts with an internal epitope of MDR3. Does not cross-react with human MDR1 P-gp.

Inmunógeno

MDR3 P-gp (amino acids 629-692) GST fusion protein.

Acciones bioquímicas o fisiológicas

Multidrug resistance protein 3 (MDR3) acts as an ATP-dependent exporter and transfers phospholipids, particularly phosphatidylcholine (PC), into bile. Dysfunctioning of MDR3 leads to excess of bile salts in primary bile and further leads to liver diseases.

Forma física

Supplied in serum-free medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable