This product is synthetic melanin, per Med. Res. Reviews 8 (1988) pp. 525-556, synthetic melanins are "eumelanin type pigments". Unfortunately, no additional information on the level of polymerization is available.
M0418
Melanin
BioReagent, Synthetic, suitable for cell culture
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About This Item
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Productos recomendados
origen biológico
synthetic
Línea del producto
BioReagent
Ensayo
≥97% (TLC)
Formulario
powder
técnicas
cell culture | mammalian: suitable
solubilidad
1 N NH4OH: 20 mg/mL
temp. de almacenamiento
−20°C
cadena SMILES
[nH]1c2c3c(c4c5c([nH]c4)c([c]([c](c5c3c1)=O)=O)C)[c]([c](c2C)=O)=O
InChI
1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
Clave InChI
XUMBMVFBXHLACL-UHFFFAOYSA-N
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Descripción general
Melanin is a distinctive class of pigment found in animals, plants, bacteria, and fungi. It is an amorphous polymer formed by the polymerization of phenolic and indolic compounds.
Aplicación
Melanin has been used:
- to incubate normal human keratinocytes for Masson-Fontana staining
- as a standard in the determination of melanin content in normal human epidermal melanocytes and immortalized human keratinocytes
- as an absorber to mimic human skin or melanocytic nevi and melanoma
Acciones bioquímicas o fisiológicas
Melanin plays a role in camouflage and energy harvesting. It also helps in protection against ionizing UV radiations, protection against biotic factors such as host defense against pathogens, and abiotic factors like heat, cold and osmotic stress. Melanin acts as a potent cation chelator and is a component of several photoprotective creams as it facilitates free radical scavenging activity. Melanin may be useful as a photo protectant in cell culture.
Nota de preparación
Prepared by oxidation of tyrosine with hydrogen peroxide.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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I wonder if you can let me know what type of melanin pigment this reagent has. Is it pheo-, eu- or mixed melanin? What is the level of polymerization? Thank you!
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