The molecular weight of this product has not been determined. However, IgG3 is cited as having a molecular weight of approximately 170 kDa. This value may vary due to post-translational modifications and glycolylation. The approximate molecular weight of the IgG3 heavy chain and kappa light chain are approximately 55 kDa and 23 kDa, respectively.
I5654
IgG3, Kappa from human myeloma plasma
purified immunoglobulin, >90% (microfluidic capillary gel electrophoresis)
Sinónimos:
Human IgG3-κ
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About This Item
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Productos recomendados
origen biológico
human
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
Ensayo
>90% (microfluidic capillary gel electrophoresis)
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
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Descripción general
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections.[1] IgG3 is the has a unique extended hinge region conferring greater flexibility
Human myeloma IgG3, κ is purified from human plasma by fractionation, ion-exchange, and affinity chromatography procedures.
Human myeloma IgG3, κ is purified from human plasma by fractionation, ion-exchange, and affinity chromatography procedures.
Aplicación
IgG3, kappa from human myeloma plasma has been used to determine the trisulfide levels in commercial therapeutic IgG1 antibodies and in human myeloma IgG1, IgG2, IgG3 and IgG4 antibodies.[2]
The purified IgG3, κ may be used as an immunoglobulin calibrator, reference antigen, blocking agent or coating protein in a variety of immunoassays including ELISA, dot-blot immunobinding, Western immunoblotting, immunodiffusion, immunoelectrophoresis, hemagglutination, and cell-binding assays. Human myeloma IgG3 was for in flow cytometry in CHO cells.[3]
Forma física
Solution in 20 mM tris buffered saline, pH 8.0.
Nota de análisis
The purity and identity are determined by immunoelectrophoresis, indirect ELISA and SDS-PAGE.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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What is the molecular weight of the Human IgG3 product I5654
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