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Merck
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Documentos clave

I2778

Sigma-Aldrich

IL-1α human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinónimos:

IL-1α, hIL-1α., Interleukin-1α human, Lymphocyte activating factor

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About This Item

Número MDL:
MFCD00164814
Código UNSPSC:
12352202
NACRES:
NA.77

Nombre del producto

Interleukin-1α human, IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

origen biológico

human

Nivel de calidad

100

recombinante

expressed in E. coli

Ensayo

≥98% (SDS-PAGE and HPLC)

Formulario

lyophilized powder

calidad

endotoxin tested

mol peso

~17 kDa

envase

pkg of 2 and 10 μg

técnicas

cell culture | mammalian: suitable

Nº de acceso UniProt

P01583

temp. de almacenamiento

−20°C

Información sobre el gen

human ... IL1A(3552)

Descripción general

Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.

Aplicación

Interleukin-1α (IL-1α) has been used:
  • to study its effects on human colorectal adenocarcinoma cells
  • to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
  • to pre-stimulate human THP-1 monocytes

Acciones bioquímicas o fisiológicas

Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.

Forma física

Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.

Nota de análisis

The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335

Consejos de prudencia

P261 - P305 + P351 + P338

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000309419
SLCQ8845
0000252244
SLCN6412
SLCP6279

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Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

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Visite la Librería de documentos

Nelson C Di Paolo et al.
Nature immunology, 17(8), 906-913 (2016-07-21)
Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection and ultimately involves the recruitment and retention of cells of hematopoietic origin, which arrive at the affected sites to resolve damage and initiate repair. Interleukin 1α (IL-1α)
Niklas Palmqvist et al.
Journal of inflammation (London, England), 13, 20-20 (2016-06-25)
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and calcineurin inhibitors. Side-effects and safety concerns associated with these agents restrict their use, and new, safe treatment
Association of interleukin1 beta, interleukin1 receptor antagonist, interleukin 6 and angiotensin II receptor type I gene polymorphisms with end stage renal disease: A meta-analysis
Divya M, et al.
Gene Reports, 100856-100856 (2020)
Peleg Rider et al.
Seminars in immunology, 25(6), 430-438 (2013-11-05)
Although the IL-1α molecule has long been recognized, information about its distinct role in various diseases is limited, since most clinical studies have focused on the role of IL-1β. Despite triggering the same IL-1 receptor as does IL-1β, there is
Ivo C J H Post et al.
Xenotransplantation, 20(1), 18-26 (2013-01-26)
Endothelial damage is a critical step in the development of (xeno) transplantation-related and cardiovascular pathology. In humans, the amount of circulating endothelial cells (CEC) correlates to disease intensity and functions as a valuable damage marker. While (xeno) transplantation and cardiovascular
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