Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

G8923

Sigma-Aldrich

GANT58

≥98% (HPLC)

Sinónimos:

2,3,4,5-Tetra(4-pyridyl)thiophene, 4,4′,4′′,4′′′-Thiene-2,3,4,5-tetrayltetrapyridine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C24H16N4S
Número de CAS:
64048-12-0
Peso molecular:
392.48
MDL number:
MFCD01103196
UNSPSC Code:
51111800
PubChem Substance ID:
329799981
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

color

white to pale yellow

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

c1cc(ccn1)-c2sc(-c3ccncc3)c(-c4ccncc4)c2-c5ccncc5

InChI

1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H

InChI key

USWLOKMMUTWFMD-UHFFFAOYSA-N

Biochem/physiol Actions

GANT58 is a Hedgehog signaling pathway inhibitor. GANT58 inhibits the hedgehog signaling pathway downstream of Smo. GANT58 inhibits Gli transcriptional activity, and reduces cellular levels of the Hh pathway components Gli1, Shh, and patched.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Alessandra Ciucci et al.
PloS one, 8(3), e60145-e60145 (2013-04-05)
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, glioblastoma, melanoma as well as pancreas, colorectal, and prostate carcinomas. Here we investigated the role of the transcription factor Gli1 in ovarian cancer.
Z I Thomas et al.
British journal of cancer, 104(10), 1575-1586 (2011-04-21)
Inflammatory breast cancer (IBC) is an aggressive subtype of breast cancer with distinct molecular profiles. Gene expression profiling previously identified sonic hedgehog (SHH) as part of a gene signature that is differentially regulated in IBC patients. The effects of reducing
Uma Thanigai Arasu et al.
Cellular and molecular life sciences : CMLS, 77(20), 4093-4115 (2019-12-11)
Intercellular communication is fundamental to the survival and maintenance of all multicellular systems, whereas dysregulation of communication pathways can drive cancer progression. Extracellular vesicles (EVs) are mediators of cell-to-cell communication that regulate a variety of cellular processes involved in tumor
Andreas Frøslev Mathisen et al.
Scientific reports, 14(1), 14669-14669 (2024-06-26)
Non-obese diabetes (NOD) mice are an established, spontaneous model of type 1 diabetes in which diabetes develops through insulitis. Using next-generation sequencing, coupled with pathway analysis, the molecular fingerprint of early insulitis was mapped in a cohort of mice ranging
Li Ma et al.
Bone, 123, 176-188 (2019-04-01)
Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico