As mentioned in the 'PROPERTIES' section, this product is supplied as a powder.
C6767
Congo Red
Dye content ≥35 %, Powder
Sinónimos:
Congo Red 4B, Cosmos Red, Cotton Red B, Cotton Red C, Direct Red 28, Direct Red R, Direct Red Y
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About This Item
Fórmula empírica (notación de Hill):
C32H22N6Na2O6S2
Número de CAS:
Peso molecular:
696.66
Colour Index Number:
22120
Beilstein/REAXYS Number:
3894858
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
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Nombre del producto
Congo Red, Dye content ≥35 %
form
powder
Quality Level
composition
Dye content, ≥35%
technique(s)
titration: suitable
color
red-brown
pH
6.7 (10 g/L)
mp
>360 °C (lit.)
solubility
H2O: 1 mg/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
[Na+].[Na+].Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c3ccc(cc3)-c4ccc(cc4)\N=N\c5cc(c6ccccc6c5N)S([O-])(=O)=O
InChI
1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/b37-35+,38-36+;;
InChI key
IQFVPQOLBLOTPF-HKXUKFGYSA-L
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Application
- Congo red has been used as a histochemical stain for the quantification of amyloid deposits in brain tissues.[1]
- It has been used as a cell wall inhibiting agent in fungus Cryptococcus neoformans.[2]
- It has also been used to study microstructural details in the cell walls of raw potato and fried potato using confocal microscopy.[3]
Biochem/physiol Actions
Congo red is a benzidine-based anionic diazo dye.[4] It is a histological dye which binds to many amyloid proteins and is used for the quantification of amyloid β-peptide aggregation.[5] Congo red also interacts with β-D-glucans, polysaccharides containing continuous β-(1→4)-linked D-glucopyranosyl units and some hemicellulosic galactoglucomannans.[6]
signalword
Danger
hcodes
Hazard Classifications
Carc. 1B - Repr. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Los clientes también vieron
Kinetic study and equilibrium isotherm analysis of Congo Red adsorption by clay materials.
Chemical Engineering Journal, 148, 354-364 (2009)
Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain.
Wilcock DM, et al.
Nature Protocols, 1, 1591-1591 (2006)
PKC1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus Cryptococcus neoformans.
Gerik KJ, et al.
Eukaryotic Cell, 7, 1685-1685 (2008)
Anat Frydman-Marom et al.
PloS one, 6(1), e16564-e16564 (2011-02-10)
An increasing body of evidence indicates that accumulation of soluble oligomeric assemblies of β-amyloid polypeptide (Aβ) play a key role in Alzheimer's disease (AD) pathology. Specifically, 56 kDa oligomeric species were shown to be correlated with impaired cognitive function in
Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay.
Klunk WE, et al.
Analytical Biochemistry, 266, 66-66 (1999)
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hello, I would like to ask about this product, is it a powder or solution? thank you.
1 answer-
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Why does the SDS for Congo Red list carcinogen as an OSHA hazard, (Section 2) but in Section 11 on carcinogenicity, it states that there is no component identified as a carcinogen?
1 answer-
The reason that there is not an OSHA listing for carcinogens on most of SDS that have a hazard of a carcinogen hazard is because that section of the SDS is specifically for the OSHA regulated carcinogens, also referred to as the OSHA 13. Congo red at this time is not specifically called out as a carcinogen by the other 3 Organizations listed (IARC, NTP, ACGIH) either. Congo red is listed by the European Classification Labeling & Packaging (CLP) Regulation (which is a pretty definitive guide for hazard classification), as a carcinogen. No other organizations have had the time to classify this material at this time. This is why it is only listed as a carcinogen in section 2 and in section 15.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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