The exact concentration will be listed on the lot specific Certificate of Analysis. Please navigate to the DOCUMENTATION section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’:https://www.sigmaaldrich.com/product/sigma/c3865#product-documentation
C3865
Anti-N-Cadherin antibody, Mouse monoclonal
clone GC-4, purified from hybridoma cell culture
Sinónimos:
Anti-A-CAM, Anti-A-Cell Adhesion Molecule
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About This Item
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origen biológico
mouse
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
GC-4, monoclonal
Formulario
buffered aqueous solution
mol peso
antigen 135 kDa
reactividad de especies
chicken, monkey, mouse, human, rabbit, rat
técnicas
electron microscopy: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections
western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts
isotipo
IgG1
Nº de acceso UniProt
aplicaciones
research pathology
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)
Categorías relacionadas
Descripción general
N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.
Aplicación
Anti-N-Cadherin antibody is suitable for the following procedures:
- electron microscopy
- flow cytometry
- immunocytochemistry[1]
- immunohistochemistry at a concentration of 10-20μg/mL using rat cardiac muscle frozen sections
- western blot at a concentration of 10-20μg/mL using chicken cardiac muscle or COS-7 cell extracts
Acciones bioquímicas o fisiológicas
CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.
Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.
Forma física
0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.
Otras notas
Clone GC-4 is also known as GB-9.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves
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