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C2505

Sigma-Aldrich

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

Sinónimos:

11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H

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About This Item

Fórmula empírica (notación de Hill):
C21H30O4
Número de CAS:
50-22-6
Peso molecular:
346.46
Beilstein:
2339601
Número CE:
200-019-6
Número MDL:
MFCD00037715
Código UNSPSC:
51111800
ID de la sustancia en PubChem:
24278302
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Corticosterone, ≥92%

origen biológico

synthetic (organic)

Ensayo

≥92%

Formulario

powder

mp

179-183 °C (lit.)

solubilidad

chloroform: 50 mg/mL, clear, colorless to faintly yellow

Condiciones de envío

ambient

temp. de almacenamiento

room temp

cadena SMILES

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

Clave InChI

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Información sobre el gen

human ... EBP(10682) , SERPINA6(866)
rat ... Ar(24208) , Nr3c1(24413)

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Aplicación

Corticosterone has been used:
  • in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice[1]
  • as a stress inducing hormone in pregnant mice[2]
  • to test its effect on depression-related behaviors in mice[3]

Acciones bioquímicas o fisiológicas

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.
Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands.[4] However, it may also be synthesized in non-adrenal tissues including leydig cells of testes[4] and in murine thymus.[5] Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress.[6] It is produced by HPA activation in response to stress in myeloid cells.[7] Elevated levels of corticosterone is observed in Huntington′s disease (HD).[8]

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000403951
0000396683
0000391934
0000403951
0000312179

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Prenatal stress alters presynaptic marker proteins in the hippocampus of rat pups
Afadlal S, et al.
Neuroscience Letters, 470(1), 24-27 (2010)
Corticosterone production during repeated social defeat causes monocyte mobilization from the bone marrow, glucocorticoid resistance, and neurovascular adhesion molecule expression
Niraula A, et al.
The Journal of Neuroscience, 38(9), 2328-2340 (2018)
Somatostatin, neuronal vulnerability and behavioral emotionality
Lin LC and Sibille E
Molecular Psychiatry, 20(3), 377-377 (2015)
Glucocorticoid production in the chicken bursa and thymus
Lechner O, et al.
International Immunology, 13(6), 769-776 (2001)
Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease
Dufour BD and McBride JL
Experimental neurology, 283(9), 308-317 (2016)
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Questions

  1. Which reagents should be used to dissolve product C2505, and what are the recommended storage conditions after it has been dissolved?

    1 answer

    1. C2505 is soluble in Chloroform at 50 mg/mL, and should be colorless to faintly yellow in appearance.

      Although we cannot provide any verified recommendations for temperature storage of solution, other literature sources suggest that the solution can remain at room temperature if the solution stays clear for 3 days. These sources suggest that it is soluble in ethanol at 50 mg/ml, and that following reconstitution, aliquot and freeze (-20°C), for stock solutions to be stable for up to 3 months (at -20°C). There are additional sources that recommend dissolving in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). It is insoluble in water.

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