We have found the information on alpha-1-antitrypsin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.The alpha-1-antitrypsin is 12 percent carbohydrate, citing K. Heide and H.G. Schwick, Chemistry and Significance of the Carbohydrate Moieties of Human Serum Glycoproteins, Angew. Chem., Int. Ed. Eng., 12, 721-733 (1973).The table also gives information on the percentage of each type of monosaccharide that is present.
A9024
α1-Antitrypsin from human plasma
salt-free, lyophilized powder
Sinónimos:
α1-Proteinase inhibitor
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About This Item
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origen biológico
human plasma
Nivel de calidad
Ensayo
≥70% protein basis (biuret)
Formulario
salt-free, lyophilized powder
temp. de almacenamiento
2-8°C
Información sobre el gen
human ... ELA2(1991) , SERPINA1(5265)
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Acciones bioquímicas o fisiológicas
1-4 mg will inhibit 1.0 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein. 1-6 mg will inhibit 1.0 mg of α-chymotrypsin with activity of >=40 BTEE units per mg protein.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.
Precaución
Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.
Nota de preparación
Chromatographically prepared and partially purified.
Cláusula de descargo de responsabilidad
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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B M Bany et al.
Biology of reproduction, 47(4), 514-519 (1992-10-01)
The objective of this study was to investigate the uterine uptake of plasma alpha 1-proteinase inhibitor (53,000 Da) and alpha 2-macroglobulin (725,000 Da) from the blood during implantation in the mouse using isotopic methods. The uterine uptake of albumin (67,000
O I Aruoma et al.
The Biochemical journal, 264(3), 863-869 (1989-12-15)
Carnosine, homocarnosine and anserine have been proposed to act as antioxidants in vivo. Our studies show that all three compounds are good scavengers of the hydroxyl radical (.OH) but that none of them can react with superoxide radical, hydrogen peroxide
O I Aruoma et al.
The Biochemical journal, 256(1), 251-255 (1988-11-15)
It has been suggested that taurine, hypotaurine and their metabolic precursors (cysteic acid, cysteamine and cysteinesulphinic acid) might act as antioxidants in vivo. The rates of their reactions with the biologically important oxidants hydroxyl radical (.OH), superoxide radical (O2.-), hydrogen
O I Aruoma et al.
FEBS letters, 244(1), 76-80 (1989-02-13)
The elastase-inhibitory activity of alpha 1-antiproteinase is inactivated by hydroxyl radicals (.OH) generated by pulse radiolysis or by reaction of iron ions with H2O2 in the presence of superoxide or ascorbate. Uric acid did not protect alpha 1-antiproteinase against inactivation
Mario Meza-Segura et al.
mBio, 12(6), e0283321-e0283321 (2021-11-03)
Shigella spp. are highly adapted pathogens that cause bacillary dysentery in human and nonhuman primates. An unusual feature of Shigella pathogenesis is that this organism invades the colonic epithelia from the basolateral pole. Therefore, it has evolved the ability to
Artículos
Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.
Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.
Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.
Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.
Protocolos
Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
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What is the carbohydrate content of human alpha-1-Antitrypsin?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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