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87917

Sigma-Aldrich

Tetramethylrhodamine ethyl ester perchlorate

suitable for fluorescence, ≥90% (HPCE)

Sinónimos:

TMRE, TMRE perchlorate

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About This Item

Fórmula empírica (notación de Hill):
C26H27ClN2O7
Número de CAS:
115532-52-0
Peso molecular:
514.95
Número MDL:
MFCD00467973
Código UNSPSC:
12352116
ID de la sustancia en PubChem:
329769616
NACRES:
NA.32

Nivel de calidad

100

Ensayo

≥90% (HPCE)

Formulario

solid

solubilidad

DMSO: soluble
alcohols: soluble

fluorescencia

λex 540 nm; λem 595 nm in DMSO

idoneidad

suitable for fluorescence

temp. de almacenamiento

2-8°C

cadena SMILES

[O-]Cl(=O)(=O)=O.CCOC(=O)c1ccccc1-c2c3ccc(cc3[o+]c4cc(ccc24)N(C)C)N(C)C

InChI

1S/C26H27N2O3.ClHO4/c1-6-30-26(29)20-10-8-7-9-19(20)25-21-13-11-17(27(2)3)15-23(21)31-24-16-18(28(4)5)12-14-22(24)25;2-1(3,4)5/h7-16H,6H2,1-5H3;(H,2,3,4,5)/q+1;/p-1

Clave InChI

NBAOBNBFGNQAEJ-UHFFFAOYSA-M

Descripción general

Tetramethylrhodamine ethyl ester perchlorate (TMRE), also known as TMRE perchlorate, is a potential mitochondrial dye. TMRE staining process is reversible, and it doesn’t affect cell proliferation and viability.

The sorted cells containing TMRE perchlorate don’t interfere with the subsequent functional assays and hence are a preferred choice for the enrichment of functionally active, unbiased cell populations.

Aplicación

Tetramethylrhodamine ethyl ester perchlorate (TMRE) is used to study the effects of high glucose in inducing mitochondrial morphology and metabolic changes.

TMRE perchlorate is also used to study Fullerene C 60 penetration into Leukemic Cells and the subsequent photoinduced Cytotoxic Effects.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Otras notas

Potential-sensitive probe for measuring membrane potential changes in mitochondria

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302 + H332,H315,H319

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCM5662
BCCK9452
BCCL3148
BCCJ8860
BCCH1421

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Natasha S Barteneva et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 62(4), 265-275 (2014-01-08)
High-speed fluorescence-activated cell sorting is relevant for a plethora of applications, such as PCR-based techniques, microarrays, cloning, and propagation of selected cell populations. We suggest a simple cell-sorting technique to eliminate early and late apoptotic and necrotic cells, with good
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Journal of biochemical and molecular toxicology, 33(8), e22337-e22337 (2019-04-09)
Elevated levels of saturated fatty acids show a strong cytotoxic effect in liver cells. Sirtuin 3 (SIRT3), a mitochondrially localized member of NAD+ -dependent deacetylase has been shown to protect hepatocytes against the oxidative stress. The role of SIRT3 on
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Molecular pharmaceutics, 16(8), 3386-3398 (2019-06-27)
Clinical trials involving p53 gene therapy for ovarian cancer failed due to the dominant negative inhibition of wild-type p53 and multiple genetic aberrations in ovarian cancer. To overcome this problem, we have designed a more potent chimeric gene fusion, called
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Nanoscale research letters, 12(1), 40-40 (2017-01-17)
Fullerene C60 as a representative of carbon nanocompounds is suggested to be promising agent for application in photodynamic therapy due to its unique physicochemical properties. The goal of this study was to estimate the accumulation of fullerene C60 in leukemic
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