Saltar al contenido
Merck
Todas las fotos(1)

Documentos

10791

Sigma-Aldrich

Antipain

>50000 U/mg

Sinónimos:

[(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C27H44N10O6
Número de CAS:
37691-11-5
Peso molecular:
604.70
Beilstein/REAXYS Number:
6837629
EC Number:
253-631-0
MDL number:
MFCD00135959
UNSPSC Code:
12352202
PubChem Substance ID:
57646816
NACRES:
NA.77

specific activity

>50000 U/mg

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

[H]C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(C)C

InChI

1S/C27H44N10O6/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)/t18?,19-,20-,21-/m0/s1

InChI key

SDNYTAYICBFYFH-KTYMLHDXSA-N

General description

Chemical structure: peptide

Biochem/physiol Actions

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.
Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Unit Definition

1 U corresponds to the amount of inhibitor which reduces the trypsin activity by 1 BAEE-U. (1 BAEE-U is the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25°C; BAEE, Cat. No. 12880, as substrate)

Other Notes

Protease inhibitor

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Los clientes también vieron

Slide 1 of 8

1 of 8

Leupeptin BioUltra, microbial, ≥95% (HPLC)

Sigma-Aldrich

L5793

Leupeptin

Benzamidine ≥95.0%

Sigma-Aldrich

12072

Benzamidine

3,4-Dichloroisocoumarin serine protease inhibitor

Sigma-Aldrich

D7910

3,4-Dichloroisocoumarin

Pepstatina A ≥100,000 U/mg

Sigma-Aldrich

77170

Pepstatina A

Leupeptin powder, from synthetic, =96.5%

Roche

LEU-RO

Leupeptin

E-64 protease inhibitor

Sigma-Aldrich

E3132

E-64

Pepstatina A from Streptomyces species

Roche

PEPS-RO

Pepstatina A

Pepstatina A microbial, ≥75% (HPLC)

Sigma-Aldrich

P4265

Pepstatina A

Alexander Belenky et al.
Clinica chimica acta; international journal of clinical chemistry, 340(1-2), 163-172 (2004-01-22)
B-type natriuretic peptide (BNP) is a cardiac hormone that regulates hemodynamic equilibrium. In the circulation, its activity is controlled by proteolytic factors. Accurate measurement of BNP in a patient's plasma may be affected by degradation due to proteolysis. We report
Sukjoon Yoon et al.
Bioinformatics (Oxford, England), 22(23), 2898-2904 (2006-10-13)
The identification of the change of gene expression in multifactorial diseases, such as breast cancer is a major goal of DNA microarray experiments. Here we present a new data mining strategy to better analyze the marginal difference in gene expression
Y Zhao et al.
American journal of physiology. Heart and circulatory physiology, 280(4), H1821-H1829 (2001-03-15)
Prekallikrein (PK) activation on human umbilical endothelial cells (HUVEC) presumably leads to bradykinin liberation. On HUVEC, PK activation requires the presence of cell-bound high-molecular-weight kininogen (HK) and Zn(2+). We examined the Zn(2+) requirement for HK binding to and the consequences
Raquel Alves Dos Santos et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(2), 671-677 (2007-10-27)
The use of antioxidants during chemotherapy has been shown to reduce or prevent the undesirable effects experienced by healthy cells. Micronutrient selenium is well known for its antioxidant properties; however, selenium exhibits a bimodal nature in that both its beneficial
E Isogai et al.
Mutation research, 403(1-2), 215-222 (1998-09-03)
In order to examine the relationship between activation of an antipain-sensitive protease and suppression of mutability in UV (UVC)-irradiated human cells, a human cell variant with the high protease activity induced by UV was established and characterized for its susceptibility
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico