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Y0000461

Torsemide

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

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About This Item

Fórmula empírica (notación de Hill):
C16H20N4O3S
Número de CAS:
56211-40-6
Peso molecular:
348.42
Número MDL:
MFCD00866166
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329830970
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

torasemide

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

Clave InChI

NGBFQHCMQULJNZ-UHFFFAOYSA-N

Información sobre el gen

human ... SLC12A1(6557)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Torasemide anhydrous EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Torsemide is a loop diuretic and inhibitor of the Na+/K+/2Cl- carrier system.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Warning

Frases de peligro

H319,H361fd

Clasificaciones de peligro

Eye Irrit. 2 - Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Gordon D Peddle et al.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 14(1), 253-259 (2012-03-01)
Diuretic therapy reduces preload and relieves congestion secondary to cardiac dysfunction. Torsemide (torasemide) is a loop diuretic with longer duration of action, decreased susceptibility to diuretic resistance, and adjunctive aldosterone antagonist properties compared with furosemide. We hypothesized that torsemide would
D V Preobrazhenskiĭ et al.
Kardiologiia, 51(4), 67-73 (2011-06-01)
Torasemide is a loop diuretic and has been used for the treatment of both acute and chronic congestive heart failure (CHF) and arterial hypertension (AH). Torasemide is similar to other loop diuretics in terms of its mechanism of diuretic action.
Mark A Oyama et al.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 13(4), 287-292 (2011-10-28)
Diuretics are a mainstay of therapy in dogs with heart failure. In dogs with advanced heart failure, moderate to high doses of loop diuretics such as furosemide are used with diminishing effects as profound activation of neuroendocrine systems promote signs
J Strobel et al.
Deutsche medizinische Wochenschrift (1946), 136(22), 1207-1210 (2011-05-26)
A 27-year-old woman was admitted to the emergency room because of dyspnoea. Two months earlier she had given birth to a healthy young boy via cesarean section. Computed tomography showed acute embolism in both pulmonary arteries. Chest X-ray and echocardiography
Sanjay Gupta et al.
European journal of heart failure, 12(7), 746-752 (2010-06-08)
Diuretics, when used to treat congestion in patients with chronic heart failure, improve symptoms and, perhaps, prognosis but little information is available to guide their use in patients with left ventricular systolic dysfunction (LVSD) who are not congested. Chronic diuretic
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