There have been no indications of instability in this material in either short-term or long-term studies. Storing the material at cooler temperatures would help minimize the risk of degradation. However, it's important to note that cannot guarantee the ongoing suitability of a standard over multiple uses.
PHR1939
Hydroxyproline
Pharmaceutical Secondary Standard; Certified Reference Material
Sinónimos:
trans-4-Hydroxy-L-proline, (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp
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About This Item
Fórmula empírica (notación de Hill):
C5H9NO3
Número de CAS:
Peso molecular:
131.13
Beilstein/REAXYS Number:
81441
EC Number:
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.24
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grade
certified reference material
pharmaceutical secondary standard
Quality Level
API family
proline
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
mp
273 °C (dec.) (lit.)
application(s)
pharmaceutical
format
neat
storage temp.
2-30°C
SMILES string
O[C@H]1CN[C@@H](C1)C(O)=O
InChI
1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI key
PMMYEEVYMWASQN-DMTCNVIQSA-N
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General description
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydroxyproline, found exclusively in collagen, is formed from the hydroxylation of proline. It is used as a biomarker to measure the collagen content of various biological samples.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydroxyproline, found exclusively in collagen, is formed from the hydroxylation of proline. It is used as a biomarker to measure the collagen content of various biological samples.
Application
This pharmaceutical secondary standard can also be used as follows:
- Multi-analysis of acetylcarnitine, proline, hydroxyproline, citrulline, and arginine as possible biomarkers by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in human plasma samples
- Simultaneous determination of proline and hydroxyproline in plasma samples by (LC-MS/MS using a new fluorescent reagent for pre-column derivatization
- Development of a micellar electrokinetic chromatography (MEKC) method to measure hydroxyproline in various dairy products upon in-capillary derivatization
- Quantitative analysis of free prolyl dipeptides, proline, and hydroxyproline by flow-gated capillary electrophoresis combined with laser-induced fluorescence detector from unhydrolyzed urine samples[1]
Other Notes
Natural constituent of animal structural proteins such as collagen and elastin.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAC2898 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
Recommended products
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
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Certificados de análisis (COA)
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Ning Zhang et al.
Analytical and bioanalytical chemistry, 409(30), 7077-7085 (2017-10-04)
Unhydrolyzed prolyl hydroxyproline (Pro-Hyp) and total 4-hydroxyproline (Hyp) in urine have been suggested as disease biomarkers for bone turnover and osteoporosis. Here, a rapid method was developed to accurately and selectively determine free prolyl compounds in unhydrolyzed urine samples. Urine
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Does the data indicate that refrigeration temperatures (2-8°C) or freezing would help maintain the stability of the amino acid standard? Additionally, is it recommended to store the powder in a desiccator to preserve its stability over time?
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