MABF111

Anti-MIF Antibody, clone M1, preservative free

clone M1, from mouse

• Sinónimos: Macrophage migration inhibitory factor, MIF, Glycosylation-inhibiting factor, GIF, L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: M1, monoclonal
• reactividad de especies: human
• técnicas: flow cytometry: suitable; neutralization: suitable; western blot: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NP_002406
• Nº de acceso UniProt: P14174
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: glycosylation
• Información sobre el gen: human ... MIF(4282)

Descripción

Descripción general

MIF, also known as Macrophage migration inhibitory factor, or Glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, L-dopachrome tautomerase, or Phenylpyruvate tautomerase, and encoded by the gene MIF/GLIF/MMIF, is proinflammatory cytokine involved in the innate immune response to bacterial pathogens. MIF is secreted by macrophages upon stimulation by bacterial lipopolysaccharide or bacterial antigens, and the expression of MIF at sites of inflammation suggests a role as a mediator in regulating the function of macrophages in host defense. MIF also counteracts the anti-inflammatory activity of glucocorticoids and has various enzyme activities but their physiological function is not known. MIF expression is primarily lymphocytes, macrophages and immune system cells. Defects in MIF may be associated with Rheumatoid arthritis systemic juvenile disease, an inflammatory articular disorder with systemic onset beginning at age 16. Also serum levels of MIF are elevated in cases of severe sepsis and are correlated with low survival.

Inmunógeno

Recombinant protein corresponding to human MIF.

Aplicación

Neutralization Assay Analysis: A representative lot from an independent laboratory detected MIF during the migration of human peripheral blood granulocytes (Rupreht, R. R., et al. (2000). Pflugers Arch. 440(5 Suppl):R78-80.).

This Anti-MIF Antibody, clone M1, preservative free is validated for use in flow cytometry, neutralizing & western blotting for the detection of MIF.

Calidad

Evaluated by Flow Cytometry by Jurkat cells.

Flow Cytometry: 1 µg of this antibody detected MIF in 1X10E6 Jurkat cells.

Descripción de destino

12 kDa calculated

Forma física

Format: Purified

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable