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AB5727

Sigma-Aldrich

Anti-Sox10 Antibody

Chemicon®, from rabbit

Sinónimos:

Anti-Sox10 antibody, Sox10 marker

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

rabbit

Nivel de calidad

100

forma del anticuerpo

affinity purified immunoglobulin

clon

polyclonal

purificado por

affinity chromatography

reactividad de especies

mouse

fabricante / nombre comercial

Chemicon®

técnicas

western blot: suitable

Nº de acceso NCBI

NM_006941.3

Nº de acceso UniProt

P56693

Condiciones de envío

wet ice

modificación del objetivo postraduccional

unmodified

Descripción general

Sox 10 is part of a family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Sox 10 is expressed in multipotent neural crest stem cells, and its expression is downregulated upon their differentiation. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

Especificidad

Sox10. The immunogen sequence is 70% conserved with Sox8 and Sox9 and therefore the antibody may show cross reactivity to these proteins.

Inmunógeno

Synthetic peptide from Sox10.

Aplicación

Anti-Sox10 Antibody detects level of Sox10 & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Neuronal & Glial Markers
Western blot: 0.1-0.5 μg/mL using ECL on fetal mouse brain tissue lysate. The antibody reacts with proteins of ~60 kDa. An additional band of ~120 kDa may also be seen depending on sample used.

Optimal working dilutions must be determined by the end user.

Descripción de destino

Approx. 55 kDa

Ligadura / enlace

Replaces: AB5774

Forma física

Affinity purified immunoglobulin. Liquid.

Almacenamiento y estabilidad

Maintain at +2-8°C in undiluted aliquots for up to 6 months after date of receipt.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury.
Keirstead, Hans S, et al.
The Journal of Neuroscience, 25, 4694-4705 (2005)
Débora Guerini Souza et al.
Journal of cellular biochemistry, 118(10), 3111-3118 (2017-04-05)
Astrocytes are versatile cells involved in synaptic information processing, energy metabolism, redox homeostasis, inflammatory response, and structural support of the brain. Recently, we established a routine protocol of cultured astrocytes derived from adult and aged Wistar rats, which present several
Jessica Jacobs-Li et al.
eLife, 12 (2023-10-25)
During development, much of the enteric nervous system (ENS) arises from the vagal neural crest that emerges from the caudal hindbrain and colonizes the entire gastrointestinal tract. However, a second ENS contribution comes from the sacral neural crest that arises
Kyohei Fujita et al.
The FEBS journal, 283(20), 3791-3806 (2016-10-21)
Neural crest-derived stem cells (NCSCs) are tissue-specific stem cells derived from multipotent neural crest cells. NCSCs are present in some adult tissues such as dorsal root ganglia, sciatic nerve, and bone marrow. However, little is known about the formation mechanisms
Na Wang et al.
Glia, 70(11), 2093-2107 (2022-07-02)
In humans, loss-of-function mutations of Kcnj10 in SeSAME/EAST syndrome, which encodes the inwardly rectifying K+ channel 4.1 (Kir 4.1), causes progressive neurological decline. Despite its rich expression in oligodendrocyte (OL) lineage cells and an emerging link with demyelinating disease, the
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