454180

2-Methoxyestradiol

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity.

• Sinónimos: 2-Methoxyestradiol, 2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene
• Fórmula empírica (notación de Hill): C₁₉H₂₆O₃
• Número de CAS: 362-07-2
• Peso molecular: 302.41
• Número MDL: MFCD00010489
• Código UNSPSC: 51111800
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥90% (HPLC)
• Formulario: crystalline solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white
• solubilidad: DMSO: soluble; ethanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• cadena SMILES: O[C@@H]1[C@@]2([C@H]([C@H]3[C@H](CC2)c4c(cc(c(c4)OC)O)CC3)CC1)C
• InChI: 1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
• Clave InChI: CQOQDQWUFQDJMK-SSTWWWIQSA-N

Descripción

Descripción general

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin and has been suggested to function as a natural regulator of microtubule assembly and function.

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits the neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Inhibits cell proliferation and angiogenesis

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Toxic (F)

Otras notas

Aizu-Yokata, E., et al. 1995. Cancer Res.55, 1863.
Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
Forsis, T., et al. 1994. Nature368, 237.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H301 + H311 + H331,H315,H319,H335,H350,H360,H372,H410
• Consejos de prudencia: P273 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable