317240

Metformin

≥97% (titration), solid, AMPK signaling activator, Calbiochem^®

• Sinónimos: Metformin, 1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
• Fórmula empírica (notación de Hill): C₄H₁₁N₅ · xHCl
• Número de CAS: 1115-70-4
• Peso molecular: 129.16 (free base basis)
• Número MDL: MFCD00012582
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Metformin, An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.
• Nivel de calidad: 100
• descripción: Merck USA index - 14, 5938
• Ensayo: ≥97% (titration)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• cadena SMILES: Cl.N(C)(C)C(=N\C(=N\[H])\N)N
• InChI: 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
• Clave InChI: OETHQSJEHLVLGH-UHFFFAOYSA-N

Descripción

Descripción general

An anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
AMP-activated protein kinase (AMPK)

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Cleasby, M.E., et al. 2004. Diabetes53, 3258.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H319
• Consejos de prudencia: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral - Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable