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Key Documents

14-486-M

Sigma-Aldrich

p70 S6 Kinase Protein, active, 10 µg

Active, N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase, for use in Kinase Assays.

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.41

biological source

human

Quality Level

recombinant

expressed in Sf21 cells

mol wt

Mw 48.7 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

UniProt accession no.

Gene Information

human ... RPS6KB1(6198)

General description

N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase
Product Source: Expressed in Sf21 cells

Biochem/physiol Actions

Protein Target: p70S6K
Target Sub-Family: AGC

Packaging

Also available in 250μg size as catalog # 14-486M.

Quality

Routinely evaluated by phosphorylation of S6 Kinase/Rsk-2 Substrate Peptide 2

Physical form

Ni2+/NTA-agarose

Storage and Stability

6 months at -70°C

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jason A Lehman et al.
The Journal of biological chemistry, 278(30), 28130-28138 (2003-05-13)
We report here for the first time the detection of the ribosomal p70S6 kinase (p70S6K) in a hematopoietic cell, the neutrophil, and the stimulation of its enzymatic activity by granulocyte macrophage colony-stimulating factor (GM-CSF). GM-CSF modified the Vmax of the

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