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06-937

Sigma-Aldrich

Anti-phospho-STAT6 (Tyr641) Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr641)

Gene Information

human ... STAT6(6778)

Categorías relacionadas

Specificity

phospho-STAT6

Immunogen

peptide corresponding to amino acids 631-645 of human STAT6 (C-PEQMGKDGRGpYVPAT)

Application

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
This Anti-phospho-STAT6 (Tyr641) Antibody is validated for use in WB for the detection of phospho-STAT6 (Tyr641).

Quality

routinely evaluated by immunoblot on lysates of HepG2 cells, serum starved, then stimulated with IL-4

Target description

100kDa

Physical form

0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.
Format: Purified
Protein A purified

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Defective GATA-3 expression in Th2 LCR-deficient mice.
Soo Seok Hwang,Kiwan Kim,Gap Ryol Lee
Biochemical and biophysical research communications null
F W Quelle et al.
Molecular and cellular biology, 15(6), 3336-3343 (1995-06-01)
By searching a database of expressed sequences, we identified a member of the signal transducers and activators of transcription (Stat) family of proteins. Human and murine full-length cDNA clones were obtained and sequenced. The sequence of the human cDNA was
Giulia Veltri et al.
Cancers, 13(15) (2021-08-08)
Lymphoblastic lymphoma (LBL) is the second most common type of non-Hodgkin lymphoma in childhood, mainly of T cell origin (T-LBL). Although current treatment protocols allow a complete remission in 85% of cases, the second-line treatment overall survival for patients with
Tetsuya Kubota et al.
Nature communications, 9(1), 4863-4863 (2018-11-20)
M2a-subtype macrophage activation is known to be impaired in obesity, although the underlying mechanisms remain poorly understood. Herein, we demonstrate that, the IL-4/Irs2/Akt pathway is selectively impaired, along with decreased macrophage Irs2 expression, although IL-4/STAT6 pathway is maintained. Indeed, myeloid
Jason C O'Connor et al.
Journal of immunology (Baltimore, Md. : 1950), 178(11), 6886-6893 (2007-05-22)
Chronic elevation of proinflammatory markers in type 2 diabetes (T2D) is well defined, but the role of anti-inflammatory cytokines in T2D is less clear. In this study, we report that normal IL-4-dependent elaboration of IL-1 receptor antagonist (IL-1RA) requires IRS-2-mediated

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