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935433

Sigma-Aldrich

Heparin methacrylate (HepMA)

Sinónimos:

3D bioprinting, Bioprinting, HepMA, Heparin, Heparin methacrylate, Hydrogel

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.21

description

Degree of functionalization: 10-30% methacrylation

Quality Level

100

form

powder or chunks (or fibers)

color

white to off-white

storage temp.

2-8°C

Categorías relacionadas

General description

Heparin methacrylate (HepMa) is a functionalized natural polymer that can be used in 3D bioprinting and tissue engineering applications.

Heparin is a naturally occurring linear biopolymer and highly sulfated glycosaminoglycan (GAG). Research has demonstrated that heparin can modulate binding extracellular matrix proteins and sequester growth factors and cytokines, making them useful in 3D applications. The methacrylate-functionalization of heparin allows thermal or photochemical crosslinking via covalent conjugation. Heparins exhibit high anionic charge densities to promote large swelling ratios in water.

Application

Heparin based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug delivery applications.

Features and Benefits

  • Batch control offers reproducible models for preclinical toxicology testing and drug screening
  • Extended shelf-life & stability

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Anastasia Nilasaroya et al.
Biomaterials, 29(35), 4658-4664 (2008-09-19)
Synthetic scaffolds show great promise for use in tissue engineering due to their ability to mimic some aspects of the extracellular matrix, however, their use has been hindered by the lack of inherent recognition sites that are required for protein
Hangjun Ding et al.
ACS nano, 8(5), 4348-4357 (2014-04-18)
The emergence of flexible and stretchable electronic components expands the range of applications of electronic devices. Flexible devices are ideally suited for electronic biointerfaces because of mechanically permissive structures that conform to curvilinear structures found in native tissue. Most electronic
Danielle S W Benoit et al.
Biomaterials, 28(1), 66-77 (2006-09-12)
Poly(ethylene glycol) (PEG) hydrogels functionalized with heparin were utilized as a three-dimensional culture system for human mesenchymal stem cells (hMSCs). Heparin-functionalized hydrogels supported hMSC viability, as quantified through live/dead imaging, and induced osteogenic differentiation, as measured by increased alkaline phosphatase

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