SRP8049
Periostin mouse
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
Sinónimos:
OSF-2, Osteoblast-specific factor 2, PC cell-derived growth factor
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Productos recomendados
biological source
mouse
recombinant
expressed in CHO cells
tag
FLAG® tagged
assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~85 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Postn(50706)
General description
Periostin (POSTN) is also called as osteoblast-specific factor 2. It is a matricellular protein, located in the alveolar walls. This gene is located on human chromosome 13q13.
Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein (BMP-2). Abnormal expression of periostin is also linked to angiogenesis and metastasis in epithelial tumors.
Biochem/physiol Actions
Periostin (POSTN) participates in collagen fibrillogenesis. It plays a major role in the development of scar after traumatic spinal cord injury (SCI). Periostin controls the activities of fibrocyte to stimulate myofibroblast differentiation and lung fibrosis. It modulates the amount of collagen in tissue. Periostin also participates in the assembly of the extracellular matrix (ECM) architecture.
Physical form
Lyophilized from PBS.
Reconstitution
Reconstitute with 100 μL deionized water.
Other Notes
Mouse periostin (aa 24-783) (isoform 5) is fused at the C-terminus to a FLAG®-tag.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Teresa Cobo et al.
PloS one, 11(1), e0147837-e0147837 (2016-01-26)
Periostin is an extracellular matrix protein highly expressed in collagen-rich tissues subjected to continuous mechanical stress. Functionally, periostin is involved in tissue remodeling and its altered function is associated to numerous pathological processes. In orthodontics, periostin plays key roles in
Periostin promotes scar formation through the interaction between pericytes and infiltrating monocytes/macrophages after spinal cord injury.
Yokota K, et al.
The American Journal of Pathology, 187(3), 639-653 (2017)
Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis.
Ashley SL, et al.
Mucosal Immunology, 10(2), 341?351-341?351 (2017)
Jin Ho Hwang et al.
American journal of nephrology, 46(6), 501-517 (2017-12-22)
Periostin is responsible for tissue regeneration, fibrosis, and wound healing via its interaction with integrin. Recently, the role of periostin has been shown to contribute to fibrosis in chronic kidney disease. We investigated the role of periostin and the effect
Nicolette M Jeanblanc et al.
Clinica chimica acta; international journal of clinical chemistry, 464, 228-235 (2016-10-19)
Periostin is being investigated as a potential biomarker for T-helper-2 (Th2)-driven asthma or eosinophilic inflammation and may help to identify patients more likely to benefit from interleukin-13-targeted treatments. We report the development and analytic performance of the investigational use only
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